Planning a girls weekend in the South? From historic coastal towns to mountain escapes and music-filled nights, these destinations for Southern girls trips offer the perfect mix of relaxation, adventure, and Instagram-worthy moments with your crew.

These bucket-list summer road trips in the United States stretch from the deserts of California and the mountains of Colorado to the beaches of the Florida Keys. Whether you’re looking to escape city life for national parks and the great outdoors, or just want to cruise down some of the most famous scenic routes in the country, these U.S. road trip vacations will not disappoint.